Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus

Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a novel class of glucuretic, antihyperglycemic drugs that target the process of renal glucose reabsorption and induce glucuresis independently of insulin secretion or action. In patients with type 2 diabetes mellitus, SGLT2 inhibitors have been f...

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Detalles Bibliográficos
Autores principales: Whaley, Jean M, Tirmenstein, Mark, Reilly, Timothy P, Poucher, Simon M, Saye, JoAnne, Parikh, Shamik, List, James F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422910/
https://www.ncbi.nlm.nih.gov/pubmed/22923998
http://dx.doi.org/10.2147/DMSO.S22503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422910/
https://www.ncbi.nlm.nih.gov/pubmed/22923998
http://dx.doi.org/10.2147/DMSO.S22503

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