AID Enzymatic Activity Is Inversely Proportional to the Size of Cytosine C5 Orbital Cloud

Activation induced deaminase (AID) deaminates cytosine to uracil, which is required for a functional humoral immune system. Previous work demonstrated, that AID also deaminates 5-methylcytosine (5 mC). Recently, a novel vertebrate modification (5-hydroxymethylcytosine - 5 hmC) has been implicated in...

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Detalles Bibliográficos
Autores principales: Rangam, Gopinath, Schmitz, Kerstin-Maike, Cobb, Alexander J. A., Petersen-Mahrt, Svend K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423351/
https://www.ncbi.nlm.nih.gov/pubmed/22916236
http://dx.doi.org/10.1371/journal.pone.0043279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423351/
https://www.ncbi.nlm.nih.gov/pubmed/22916236
http://dx.doi.org/10.1371/journal.pone.0043279

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