Modeling of Arylamide Helix Mimetics in the p53 Peptide Binding Site of hDM2 Suggests Parallel and Anti-Parallel Conformations Are Both Stable

The design of novel α-helix mimetic inhibitors of protein-protein interactions is of interest to pharmaceuticals and chemical genetics researchers as these inhibitors provide a chemical scaffold presenting side chains in the same geometry as an α-helix. This conformational arrangement allows the des...

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Detalles Bibliográficos
Autores principales: Fuller, Jonathan C., Jackson, Richard M., Edwards, Thomas A., Wilson, Andrew J., Shirts, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423354/
https://www.ncbi.nlm.nih.gov/pubmed/22916232
http://dx.doi.org/10.1371/journal.pone.0043253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423354/
https://www.ncbi.nlm.nih.gov/pubmed/22916232
http://dx.doi.org/10.1371/journal.pone.0043253

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