Exploiting the MDM2-CK1α Protein-Protein Interface to Develop Novel Biologics That Induce UBL-Kinase-Modification and Inhibit Cell Growth

Protein-protein interactions forming dominant signalling events are providing ever-growing platforms for the development of novel Biologic tools for controlling cell growth. Casein Kinase 1 α (CK1α) forms a genetic and physical interaction with the murine double minute chromosome 2 (MDM2) oncoprotei...

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Detalles Bibliográficos
Autores principales: Huart, Anne-Sophie, MacLaine, Nicola J., Narayan, Vikram, Hupp, Ted R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423359/
https://www.ncbi.nlm.nih.gov/pubmed/22916255
http://dx.doi.org/10.1371/journal.pone.0043391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423359/
https://www.ncbi.nlm.nih.gov/pubmed/22916255
http://dx.doi.org/10.1371/journal.pone.0043391

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