Domain organization differences explain Bcr-Abl’s preference for CrkL over CrkII

CrkL is a key signaling protein that mediates the leukemogenic activity of Bcr-Abl. CrkL is thought to adopt a structure that is similar to that of its CrkII homolog. The two proteins share high sequence identity and indistinguishable ligand binding preferences; yet they have distinct physiological...

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Detalles Bibliográficos
Autores principales: Jankowski, Wojciech, Saleh, Tamjeed, Pai, Ming-Tao, Sriram, Ganapathy, Birge, Raymond B., Kalodimos, Charalampos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423979/
https://www.ncbi.nlm.nih.gov/pubmed/22581121
http://dx.doi.org/10.1038/nchembio.954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423979/
https://www.ncbi.nlm.nih.gov/pubmed/22581121
http://dx.doi.org/10.1038/nchembio.954

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