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Effect of rubbing on the in vitro skin permeation of diclofenac-diethylamine 1.16% gel
BACKGROUND: Rubbing a topical NSAID (non steroidal anti-inflammatory drug) on the skin may increase local drug permeation, affecting its distribution to the site of pain and inflammation. The present study evaluates this hypothesis, by assessing in vitro the effect on skin permeation of applying dic...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424122/ https://www.ncbi.nlm.nih.gov/pubmed/22720797 http://dx.doi.org/10.1186/1756-0500-5-321 |