The counter regulatory response induced by CpG oligonucleotides prevents bleomycin induced pneumopathy

Bleomycin (BLM) induces life-threatening pneumonitis and pulmonary fibrosis in 20% of patients, limiting its use as a chemotherapeutic agent. Oligonucleotides expressing immunostimulatory CpG motifs (CpG ODN) stimulate cells that express Toll-like receptor 9 to initiate an inflammatory response. Thi...

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Detalles Bibliográficos
Autores principales: Kinjo, Takeshi, Tomaru, Koji, Haines, Diana C, Klinman, Dennis M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424146/
https://www.ncbi.nlm.nih.gov/pubmed/22708497
http://dx.doi.org/10.1186/1465-9921-13-47

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424146/
https://www.ncbi.nlm.nih.gov/pubmed/22708497
http://dx.doi.org/10.1186/1465-9921-13-47

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