Biological and Biochemical Characterization of Mice Expressing Prion Protein Devoid of the Octapeptide Repeat Region after Infection with Prions

Accumulating lines of evidence indicate that the N-terminal domain of prion protein (PrP) is involved in prion susceptibility in mice. In this study, to investigate the role of the octapeptide repeat (OR) region alone in the N-terminal domain for the susceptibility and pathogenesis of prion disease,...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamaguchi, Yoshitaka, Miyata, Hironori, Uchiyama, Keiji, Ootsuyama, Akira, Inubushi, Sachiko, Mori, Tsuyoshi, Muramatsu, Naomi, Katamine, Shigeru, Sakaguchi, Suehiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424169/
https://www.ncbi.nlm.nih.gov/pubmed/22927985
http://dx.doi.org/10.1371/journal.pone.0043540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424169/
https://www.ncbi.nlm.nih.gov/pubmed/22927985
http://dx.doi.org/10.1371/journal.pone.0043540

Ejemplares similares