RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells

Homologous recombination serves multiple roles in DNA repair that are essential for maintaining genomic stability. We here describe RI-1, a small molecule that inhibits the central recombination protein RAD51. RI-1 specifically reduces gene conversion in human cells while stimulating single strand a...

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Detalles Bibliográficos
Autores principales: Budke, Brian, Logan, Hillary L., Kalin, Jay H., Zelivianskaia, Anna S., Cameron McGuire, William, Miller, Luke L., Stark, Jeremy M., Kozikowski, Alan P., Bishop, Douglas K., Connell, Philip P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424541/
https://www.ncbi.nlm.nih.gov/pubmed/22573178
http://dx.doi.org/10.1093/nar/gks353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424541/
https://www.ncbi.nlm.nih.gov/pubmed/22573178
http://dx.doi.org/10.1093/nar/gks353

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