Cargando…

RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells

Homologous recombination serves multiple roles in DNA repair that are essential for maintaining genomic stability. We here describe RI-1, a small molecule that inhibits the central recombination protein RAD51. RI-1 specifically reduces gene conversion in human cells while stimulating single strand a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Budke, Brian, Logan, Hillary L., Kalin, Jay H., Zelivianskaia, Anna S., Cameron McGuire, William, Miller, Luke L., Stark, Jeremy M., Kozikowski, Alan P., Bishop, Douglas K., Connell, Philip P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424541/ https://www.ncbi.nlm.nih.gov/pubmed/22573178 http://dx.doi.org/10.1093/nar/gks353

Ejemplares similares

RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells
por: Mason, Jennifer M., et al.
Publicado: (2015)

Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption
por: Colavito, Sierra, et al.
Publicado: (2009)

LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA
por: Shen, Liping, et al.
Publicado: (2018)

Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum
por: Genois, Marie-Michelle, et al.
Publicado: (2015)

TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair
por: Hariharasudhan, Gurusamy, et al.
Publicado: (2022)

The homologous recombination protein RAD51D protects the genome from large deletions
por: Reh, Wade A., et al.
Publicado: (2017)

Role of the RAD51–SWI5–SFR1 Ensemble in homologous recombination
por: Su, Guan-Chin, et al.
Publicado: (2016)

The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55–Rad57 to mediate error-free recombination
por: Godin, Stephen, et al.
Publicado: (2013)

Detection of novel recombinases in bacteriophage genomes unveils Rad52, Rad51 and Gp2.5 remote homologs
por: Lopes, Anne, et al.
Publicado: (2010)

GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination
por: Takizawa, Yoshimasa, et al.
Publicado: (2010)

Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum
por: Genois, Marie-Michelle, et al.
Publicado: (2012)

Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation
por: Bakr, A., et al.
Publicado: (2015)

Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction
por: Subramanyam, Shyamal, et al.
Publicado: (2013)

DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange
por: Ishida, Takako, et al.
Publicado: (2009)

Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation
por: Zelensky, Alex N., et al.
Publicado: (2013)

RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases
por: Guh, Chia-Lun, et al.
Publicado: (2023)

Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament
por: Ma, Chu Jian, et al.
Publicado: (2017)

The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing
por: Kelso, Andrew A., et al.
Publicado: (2017)

NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability
por: Parplys, Ann C., et al.
Publicado: (2015)

FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5′-DNA end
por: Sato, Koichi, et al.
Publicado: (2016)

Human RAD51 paralogue RAD51C fosters repair of alkylated DNA by interacting with the ALKBH3 demethylase
por: Mohan, Monisha, et al.
Publicado: (2019)

Caffeine inhibits gene conversion by displacing Rad51 from ssDNA
por: Tsabar, Michael, et al.
Publicado: (2015)

Homologous recombination in budding yeast expressing the human RAD52 gene reveals a Rad51-independent mechanism of conservative double-strand break repair
por: Manthey, Glenn M., et al.
Publicado: (2017)

Cooperation of RAD51 and RAD54 in regression of a model replication fork
por: Bugreev, Dmitry V., et al.
Publicado: (2011)

The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart
por: Zhang, Qianting, et al.
Publicado: (2023)

The splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesion
por: Rajesh, Changanamkandath, et al.
Publicado: (2011)

Inter-subunit interactions that coordinate Rad51's activities
por: Grigorescu, Arabela A., et al.
Publicado: (2009)

ATP-dependent nucleosome unwrapping catalyzed by human RAD51
por: North, Justin A., et al.
Publicado: (2013)

Conformational flexibility and oligomerization of BRCA2 regions induced by RAD51 interaction
por: Sidhu, Arshdeep, et al.
Publicado: (2020)

Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency
por: Di Domenico, Enea Gino, et al.
Publicado: (2013)

RAD51 and RTEL1 compensate telomere loss in the absence of telomerase
por: Olivier, Margaux, et al.
Publicado: (2018)

RAD51 interconnects between DNA replication, DNA repair and immunity
por: Bhattacharya, Souparno, et al.
Publicado: (2017)

RADX condenses single-stranded DNA to antagonize RAD51 loading
por: Zhang, Hongshan, et al.
Publicado: (2020)

Microcephaly family protein MCPH1 stabilizes RAD51 filaments
por: Chang, Hao-Yen, et al.
Publicado: (2020)

Significance of ligand interactions involving Hop2-Mnd1 and the RAD51 and DMC1 recombinases in homologous DNA repair and XX ovarian dysgenesis
por: Zhao, Weixing, et al.
Publicado: (2015)

Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation
por: Onaka, Atsushi T., et al.
Publicado: (2016)

FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability
por: Liu, Wenpeng, et al.
Publicado: (2023)

Noncanonical NF-κB factor p100/p52 regulates homologous recombination and modulates sensitivity to DNA-damaging therapy
por: Budke, Brian, et al.
Publicado: (2022)

RAD51B plays an essential role during somatic and meiotic recombination in Physcomitrella
por: Charlot, Florence, et al.
Publicado: (2014)

A cell-penetrating antibody inhibits human RAD51 via direct binding
por: Turchick, Audrey, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_8naerdfe6fr9ovc9pv2du75be5