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A small ribozyme with dual-site kinase activity

Phosphoryl transfer onto backbone hydroxyls is a recognized catalytic activity of nucleic acids. We find that kinase ribozyme K28 possesses an unusually complex active site that promotes (thio)phosphorylation of two residues widely separated in primary sequence. After allowing the ribozyme to radiol...

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Detalles Bibliográficos
Autores principales: Biondi, Elisa, Maxwell, Adam W.R., Burke, Donald H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424543/
https://www.ncbi.nlm.nih.gov/pubmed/22618879
http://dx.doi.org/10.1093/nar/gks356