The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures

Werner’s syndrome (WS) and Bloom’s syndrome (BS) are cancer predisposition disorders caused by loss of function of the RecQ helicases WRN or BLM, respectively. BS and WS are characterized by replication defects, hyperrecombination events and chromosomal aberrations, which are hallmarks of cancer. In...

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Detalles Bibliográficos
Autores principales: Barefield, Colleen, Karlseder, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424559/
https://www.ncbi.nlm.nih.gov/pubmed/22576367
http://dx.doi.org/10.1093/nar/gks407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424559/
https://www.ncbi.nlm.nih.gov/pubmed/22576367
http://dx.doi.org/10.1093/nar/gks407

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