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The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures
Werner’s syndrome (WS) and Bloom’s syndrome (BS) are cancer predisposition disorders caused by loss of function of the RecQ helicases WRN or BLM, respectively. BS and WS are characterized by replication defects, hyperrecombination events and chromosomal aberrations, which are hallmarks of cancer. In...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424559/ https://www.ncbi.nlm.nih.gov/pubmed/22576367 http://dx.doi.org/10.1093/nar/gks407 |