Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island

Repression of many tumor suppressor genes in cancer is concurrent with aberrantly increased DNA methylation levels at promoter CpG islands (CGIs). About one-fourth of empirically defined human promoters are surrounded by or contain clustered repetitive elements. It was previously observed that a sha...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, Shu, Jingmin, Si, Jiali, Shen, Lanlan, Estecio, Marcos R.H., Issa, Jean-Pierre J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424568/
https://www.ncbi.nlm.nih.gov/pubmed/22600741
http://dx.doi.org/10.1093/nar/gks429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424568/
https://www.ncbi.nlm.nih.gov/pubmed/22600741
http://dx.doi.org/10.1093/nar/gks429

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