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Role of ATP binding and hydrolysis in the gating of the cystic fibrosis transmembrane conductance regulator

The CFTR gene is unique within the ATP-binding cassette (ABC) protein family, predominantly of transporters, by coding a chloride channel. The gating mechanism of ABC proteins has been characterized by the ATP Switch model in terms cycles of dimer formation and dissociation linked to ATP binding and...

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Detalles Bibliográficos
Autor principal: Gout, Taras
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425041/
https://www.ncbi.nlm.nih.gov/pubmed/22924067
http://dx.doi.org/10.4103/1817-1737.98842