Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

BACKGROUND: The sphingosine 1-phosphate (S1P) receptor modulator FTY720P (Gilenya®) potently reduces relapse rate and lesion activity in the neuroinflammatory disorder multiple sclerosis. Although most of its efficacy has been shown to be related to immunosuppression through the induction of lymphop...

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Detalles Bibliográficos
Autores principales: van Doorn, Ruben, Lopes Pinheiro, Melissa A, Kooij, Gijs, Lakeman, Kim, van het Hof, Bert, van der Pol, Susanne MA, Geerts, Dirk, van Horssen, Jack, van der Valk, Paul, van der Kam, Elizabeth, Ronken, Eric, Reijerkerk, Arie, de Vries, Helga E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425155/
https://www.ncbi.nlm.nih.gov/pubmed/22715976
http://dx.doi.org/10.1186/1742-2094-9-133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425155/
https://www.ncbi.nlm.nih.gov/pubmed/22715976
http://dx.doi.org/10.1186/1742-2094-9-133

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