Hyperglycemia Causes Renal Cell Damage via CCN2-Induced Activation of the TrkA Receptor: Implications for Diabetic Nephropathy

CCN2, a secreted profibrotic protein, is highly expressed in diabetic nephropathy (DN) and implicated in its pathogenesis; however, the actions of CCN2 in DN remain elusive. We previously demonstrated that CCN2 triggers signaling via tropomyosin receptor kinase A (TrkA). Trace expression of TrkA is...

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Detalles Bibliográficos
Autores principales: Fragiadaki, Maria, Hill, Nicola, Hewitt, Reiko, Bou-Gharios, George, Cook, Terence, Tam, Frederick W., Domin, Jan, Mason, Roger M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425410/
https://www.ncbi.nlm.nih.gov/pubmed/22586581
http://dx.doi.org/10.2337/db11-1138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425410/
https://www.ncbi.nlm.nih.gov/pubmed/22586581
http://dx.doi.org/10.2337/db11-1138

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