Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice

We recently demonstrated that reducing IGF-1 receptor (IGF-1R) numbers in the endothelium enhances nitric oxide (NO) bioavailability and endothelial cell insulin sensitivity. In the present report, we aimed to examine the effect of increasing IGF-1R on endothelial cell function and repair. To examin...

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Detalles Bibliográficos
Autores principales: Imrie, Helen, Viswambharan, Hema, Sukumar, Piruthivi, Abbas, Afroze, Cubbon, Richard M., Yuldasheva, Nadira, Gage, Matthew, Smith, Jessica, Galloway, Stacey, Skromna, Anna, Rashid, Sheik Taqweer, Futers, T. Simon, Xuan, Shouhong, Gatenby, V. Kate, Grant, Peter J., Channon, Keith M., Beech, David J., Wheatcroft, Stephen B., Kearney, Mark T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Pathophysiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425420/
https://www.ncbi.nlm.nih.gov/pubmed/22733797
http://dx.doi.org/10.2337/db11-1494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425420/
https://www.ncbi.nlm.nih.gov/pubmed/22733797
http://dx.doi.org/10.2337/db11-1494

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