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DNA Double Strand Breaks but Not Interstrand Crosslinks Prevent Progress through Meiosis in Fully Grown Mouse Oocytes

There is some interest in how mammalian oocytes respond to different types of DNA damage because of the increasing expectation of fertility preservation in women undergoing chemotherapy. Double strand breaks (DSBs) induced by ionizing radiation and agents such as neocarzinostatin (NCS), and interstr...

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Detalles Bibliográficos
Autores principales: Yuen, Wai Shan, Merriman, Julie A., O'Bryan, Moira K., Jones, Keith T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425511/
https://www.ncbi.nlm.nih.gov/pubmed/22928046
http://dx.doi.org/10.1371/journal.pone.0043875