Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHβE Suggests a Unique Mode of Antagonism

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that belong to the Cys-loop receptor superfamily. These receptors are allosteric proteins that exist in different conformational states, including resting (closed), activated (open), and desensitized (closed) states....

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Detalles Bibliográficos
Autores principales: Shahsavar, Azadeh, Kastrup, Jette S., Nielsen, Elsebet Ø., Kristensen, Jesper L., Gajhede, Michael, Balle, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425559/
https://www.ncbi.nlm.nih.gov/pubmed/22927902
http://dx.doi.org/10.1371/journal.pone.0040757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425559/
https://www.ncbi.nlm.nih.gov/pubmed/22927902
http://dx.doi.org/10.1371/journal.pone.0040757

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