Divergent roles of Smad3 and PI3-kinase in murine adriamycin nephropathy indicate distinct mechanisms of proteinuria and fibrogenesis

Multiple transforming growth factor (TGF)-β-induced fibrogenic signals have been described in vitro. To evaluate mechanisms in vivo, we used an adriamycin nephropathy model in 129x1/Svj mice that display massive proteinuria by day 5 to7 and pathological findings similar to human focal segmental glom...

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Detalles Bibliográficos
Autores principales: Finer, Gal, Schnaper, H. William, Kanwar, Yashpal S., Liang, Xiaoyan, Lin, Herbert Y., Hayashida, Tomoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425729/
https://www.ncbi.nlm.nih.gov/pubmed/22534961
http://dx.doi.org/10.1038/ki.2012.139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425729/
https://www.ncbi.nlm.nih.gov/pubmed/22534961
http://dx.doi.org/10.1038/ki.2012.139

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