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Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases

Alterations in glycosphingolipid (GSL) production results in lysosomal storage disorders associated with neurodegenerative changes. In Gaucher’s disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL metabolism. The role of GSLs in osteocl...

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Detalles Bibliográficos
Autores principales: Ersek, Adel, Karadimitris, Anastasios, Horwood, Nicole J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425772/
https://www.ncbi.nlm.nih.gov/pubmed/22936926
http://dx.doi.org/10.3389/fendo.2012.00106