Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases

Alterations in glycosphingolipid (GSL) production results in lysosomal storage disorders associated with neurodegenerative changes. In Gaucher’s disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL metabolism. The role of GSLs in osteocl...

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Autores principales: Ersek, Adel, Karadimitris, Anastasios, Horwood, Nicole J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425772/
https://www.ncbi.nlm.nih.gov/pubmed/22936926
http://dx.doi.org/10.3389/fendo.2012.00106
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author Ersek, Adel
Karadimitris, Anastasios
Horwood, Nicole J.
author_facet Ersek, Adel
Karadimitris, Anastasios
Horwood, Nicole J.
author_sort Ersek, Adel
collection PubMed
description Alterations in glycosphingolipid (GSL) production results in lysosomal storage disorders associated with neurodegenerative changes. In Gaucher’s disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL metabolism. The role of GSLs in osteoclast and osteoblast formation is discussed here as well as the potential therapeutic uses of already approved drugs that limit GSL production in bone loss disorders such as multiple myeloma and periodontal disease.
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spelling pubmed-34257722012-08-30 Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases Ersek, Adel Karadimitris, Anastasios Horwood, Nicole J. Front Endocrinol (Lausanne) Endocrinology Alterations in glycosphingolipid (GSL) production results in lysosomal storage disorders associated with neurodegenerative changes. In Gaucher’s disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL metabolism. The role of GSLs in osteoclast and osteoblast formation is discussed here as well as the potential therapeutic uses of already approved drugs that limit GSL production in bone loss disorders such as multiple myeloma and periodontal disease. Frontiers Research Foundation 2012-08-23 /pmc/articles/PMC3425772/ /pubmed/22936926 http://dx.doi.org/10.3389/fendo.2012.00106 Text en Copyright © Ersek, Karadimitris and Horwood. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Endocrinology
Ersek, Adel
Karadimitris, Anastasios
Horwood, Nicole J.
Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases
title Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases
title_full Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases
title_fullStr Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases
title_full_unstemmed Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases
title_short Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases
title_sort effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425772/
https://www.ncbi.nlm.nih.gov/pubmed/22936926
http://dx.doi.org/10.3389/fendo.2012.00106
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