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A Carboxy-Terminal Trimerization Domain Stabilizes Conformational Epitopes on the Stalk Domain of Soluble Recombinant Hemagglutinin Substrates

Recently, a new class of broadly neutralizing anti-influenza virus antibodies that target the stalk domain of the viral hemagglutinin was discovered. As such, induction, isolation, characterization, and quantification of these novel antibodies has become an area of intense research and great interes...

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Detalles Bibliográficos
Autores principales: Krammer, Florian, Margine, Irina, Tan, Gene S., Pica, Natalie, Krause, Jens C., Palese, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426533/
https://www.ncbi.nlm.nih.gov/pubmed/22928001
http://dx.doi.org/10.1371/journal.pone.0043603