Cargando…

A Carboxy-Terminal Trimerization Domain Stabilizes Conformational Epitopes on the Stalk Domain of Soluble Recombinant Hemagglutinin Substrates

Recently, a new class of broadly neutralizing anti-influenza virus antibodies that target the stalk domain of the viral hemagglutinin was discovered. As such, induction, isolation, characterization, and quantification of these novel antibodies has become an area of intense research and great interes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krammer, Florian, Margine, Irina, Tan, Gene S., Pica, Natalie, Krause, Jens C., Palese, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426533/ https://www.ncbi.nlm.nih.gov/pubmed/22928001 http://dx.doi.org/10.1371/journal.pone.0043603

Ejemplares similares

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain
por: Steel, John, et al.
Publicado: (2010)

An Inactivated Influenza Virus Vaccine Approach to Targeting the Conserved Hemagglutinin Stalk and M2e Domains
por: Sun, Weina, et al.
Publicado: (2019)

An immuno-assay to quantify influenza virus hemagglutinin with correctly folded stalk domains in vaccine preparations
por: Rajendran, Madhusudan, et al.
Publicado: (2018)

The influenza virus hemagglutinin head evolves faster than the stalk domain
por: Kirkpatrick, Ericka, et al.
Publicado: (2018)

Adjuvants and Immunization Strategies to Induce Influenza Virus Hemagglutinin Stalk Antibodies
por: Goff, Peter H., et al.
Publicado: (2013)

Enhanced Immunogenicity of Stabilized Trimeric Soluble Influenza Hemagglutinin
por: Weldon, William C., et al.
Publicado: (2010)

Age Dependence and Isotype Specificity of Influenza Virus Hemagglutinin Stalk-Reactive Antibodies in Humans
por: Nachbagauer, Raffael, et al.
Publicado: (2016)

Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model
por: Roubidoux, Ericka Kirkpatrick, et al.
Publicado: (2021)

Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain
por: Anderson, Christopher S., et al.
Publicado: (2017)

On the computational ability of the RNA polymerase II carboxy terminal domain
por: Karagiannis, Jim
Publicado: (2014)

Influenza chimeric hemagglutinin structures in complex with broadly protective antibodies to the stem and trimer interface
por: Zhu, Xueyong, et al.
Publicado: (2022)

Decoding the informational properties of the RNA polymerase II Carboxy Terminal Domain
por: Karagiannis, Jim
Publicado: (2012)

Trimeric structure and conformational equilibrium of M-ficolin fibrinogen-like domain
por: Tanio, Michikazu, et al.
Publicado: (2008)

Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain
por: Liefhebber, Jolanda MP, et al.
Publicado: (2009)

Further Characterization of Functional Domains of PerA, Role of Amino and Carboxy Terminal Domains in DNA Binding
por: Ibarra, J. Antonio, et al.
Publicado: (2013)

Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development
por: Khanna, Madhu, et al.
Publicado: (2014)

Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain
por: Anderson, Christopher S., et al.
Publicado: (2018)

Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain
por: Anderson, Christopher S., et al.
Publicado: (2018)

The Hemagglutinin-Neuraminidase (HN) Head Domain and the Fusion (F) Protein Stalk Domain of the Parainfluenza Viruses Affect the Specificity of the HN-F Interaction
por: Tsurudome, Masato, et al.
Publicado: (2018)

A single-shot adenoviral vaccine provides hemagglutinin stalk-mediated protection against heterosubtypic influenza challenge in mice
por: Bliss, Carly M., et al.
Publicado: (2022)

Molecular dissection of radixin: distinct and interdependent functions of the amino- and carboxy-terminal domains
Publicado: (1995)

Exploring the Ability of LARS2 Carboxy-Terminal Domain in Rescuing the MELAS Phenotype
por: Capriglia, Francesco, et al.
Publicado: (2021)

Group 1 and group 2 hemagglutinin stalk antibody response according to age
por: Sánchez-de Prada, Laura, et al.
Publicado: (2023)

The carboxy-terminal domain of Gs alpha is necessary for anchorage of the activated form in the plasma membrane
Publicado: (1990)

In vivo evidence for the involvement of the carboxy terminal domain in assembling connexin 36 at the electrical synapse
por: Helbig, Ingo, et al.
Publicado: (2010)

Importance of the GluN2B carboxy-terminal domain for enhancement of social memories
por: Jacobs, Stephanie, et al.
Publicado: (2015)

Driving forces behind phase separation of the carboxy-terminal domain of RNA polymerase II
por: Flores-Solis, David, et al.
Publicado: (2023)

Carboxy terminal modifications of the P0 protein reveal alternative mechanisms of nuclear ribosomal stalk assembly
por: Francisco-Velilla, Rosario, et al.
Publicado: (2013)

Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner
por: Mullarkey, Caitlin E., et al.
Publicado: (2016)

Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens
por: Kar, Uddipan, et al.
Publicado: (2022)

Potentiation of Neuronal Nicotinic Receptors by 17β-Estradiol: Roles of the Carboxy-Terminal and the Amino-Terminal Extracellular Domains
por: Jin, Xiaochun, et al.
Publicado: (2015)

PORCN Negatively Regulates AMPAR Function Independently of Subunit Composition and the Amino-Terminal and Carboxy-Terminal Domains of AMPARs
por: Wei, Mengping, et al.
Publicado: (2020)

Sec2 protein contains a coiled-coil domain essential for vesicular transport and a dispensable carboxy terminal domain
Publicado: (1990)

Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection
por: Tan, Gene S., et al.
Publicado: (2016)

Phosphorylation of the carboxy-terminal domain of histone H1: effects on secondary structure and DNA condensation
por: Roque, Alicia, et al.
Publicado: (2008)

The Carboxy-Terminal Domain of Dictyostelium C-Module-Binding Factor Is an Independent Gene Regulatory Entity
por: Lucas, Jörg, et al.
Publicado: (2009)

Structural Organization of Pregenomic RNA and the Carboxy-Terminal Domain of the Capsid Protein of Hepatitis B Virus
por: Wang, Joseph C.-Y., et al.
Publicado: (2012)

Post-translational modifications of HTLV-1 Tax carboxy-terminal domain: role in cellular transformation
por: Lodewick, Julie, et al.
Publicado: (2014)

The Carboxy-Terminal Domain of Erb1 Is a Seven-Bladed ß-Propeller that Binds RNA
por: Marcin, Wegrecki, et al.
Publicado: (2015)

Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model
por: Jacobsen, Henning, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_p5pq381tpdf7i7hu7mitm87sd4