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A voltage-gated sodium channel is essential for the positive selection of CD4(+) T cells
Sustained Ca(2+) entry into CD4(+)CD8(+) double-positive thymocytes is required for positive selection. We identified a voltage-gated Na(+) channel (VGSC), essential for positive selection of CD4(+) T cells. Pharmacological inhibition of VGSC activity inhibitedsustained Ca(2+) influx induced by posi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426661/ https://www.ncbi.nlm.nih.gov/pubmed/22842345 http://dx.doi.org/10.1038/ni.2379 |