FunSAV: Predicting the Functional Effect of Single Amino Acid Variants Using a Two-Stage Random Forest Model

Single amino acid variants (SAVs) are the most abundant form of known genetic variations associated with human disease. Successful prediction of the functional impact of SAVs from sequences can thus lead to an improved understanding of the underlying mechanisms of why a SAV may be associated with ce...

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Detalles Bibliográficos
Autores principales: Wang, Mingjun, Zhao, Xing-Ming, Takemoto, Kazuhiro, Xu, Haisong, Li, Yuan, Akutsu, Tatsuya, Song, Jiangning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427247/
https://www.ncbi.nlm.nih.gov/pubmed/22937107
http://dx.doi.org/10.1371/journal.pone.0043847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427247/
https://www.ncbi.nlm.nih.gov/pubmed/22937107
http://dx.doi.org/10.1371/journal.pone.0043847

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