DNA methylation analyses of urothelial carcinoma reveal distinct epigenetic subtypes and an association between gene copy number and methylation status

We assessed DNA methylation and copy number status of 27,000 CpGs in 149 urothelial carcinomas and integrated the findings with gene expression and mutation data. Methylation was associated with gene expression for 1,332 CpGs, of which 26% showed positive correlation with expression, i.e., high meth...

Descripción completa

Detalles Bibliográficos
Autores principales: Lauss, Martin, Aine, Mattias, Sjödahl, Gottfrid, Veerla, Srinivas, Patschan, Oliver, Gudjonsson, Sigurdur, Chebil, Gunilla, Lövgren, Kristina, Fernö, Mårten, Månsson, Wiking, Liedberg, Fredrik, Ringnér, Markus, Lindgren, David, Höglund, Mattias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427281/
https://www.ncbi.nlm.nih.gov/pubmed/22705924
http://dx.doi.org/10.4161/epi.20837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427281/
https://www.ncbi.nlm.nih.gov/pubmed/22705924
http://dx.doi.org/10.4161/epi.20837

Ejemplares similares