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DNA methylation analyses of urothelial carcinoma reveal distinct epigenetic subtypes and an association between gene copy number and methylation status
We assessed DNA methylation and copy number status of 27,000 CpGs in 149 urothelial carcinomas and integrated the findings with gene expression and mutation data. Methylation was associated with gene expression for 1,332 CpGs, of which 26% showed positive correlation with expression, i.e., high meth...
Autores principales: | Lauss, Martin, Aine, Mattias, Sjödahl, Gottfrid, Veerla, Srinivas, Patschan, Oliver, Gudjonsson, Sigurdur, Chebil, Gunilla, Lövgren, Kristina, Fernö, Mårten, Månsson, Wiking, Liedberg, Fredrik, Ringnér, Markus, Lindgren, David, Höglund, Mattias |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427281/ https://www.ncbi.nlm.nih.gov/pubmed/22705924 http://dx.doi.org/10.4161/epi.20837 |
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