Tubulin-Destabilizing Agent BPR0L075 Induces Vascular-Disruption in Human Breast Cancer Mammary Fat Pad Xenografts

BPR0L075, 6-methoxy-3-(3′,4′,5′-trimethoxy-benzoyl)-1H-indole, is a tubulin-binding agent that inhibits tubulin polymerization by binding to the colchicine-binding site. BPR0L075 has shown antimitotic and antiangiogenic activity in vitro. The current study evaluated the vascular-disrupting activity...

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Detalles Bibliográficos
Autores principales: Liu, Li, Beck, Haley, Wang, Xiaolei, Hsieh, Hsing-Pang, Mason, Ralph P., Liu, Xinli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427339/
https://www.ncbi.nlm.nih.gov/pubmed/22937031
http://dx.doi.org/10.1371/journal.pone.0043314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427339/
https://www.ncbi.nlm.nih.gov/pubmed/22937031
http://dx.doi.org/10.1371/journal.pone.0043314

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