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Leu128(3.43) (L128) and Val247(6.40) (V247) of CXCR1 Are Critical Amino Acid Residues for G Protein Coupling and Receptor Activation
CXCR1, a classic GPCR that binds IL-8, plays a key role in neutrophil activation and migration by activating phospholipase C (PLC)β through Gα(15) and Gα(i) which generates diacylglycerol and inositol phosphates (IPs). In this study, two conserved amino acid residues of CXCR1 on the transmembrane do...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427349/ https://www.ncbi.nlm.nih.gov/pubmed/22936990 http://dx.doi.org/10.1371/journal.pone.0042765 |