AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation

AID/APOBEC family cytosine deaminases, known to function in diverse cellular processes from antibody diversification to mRNA editing, have also been implicated in DNA demethylation, an important process for transcriptional activation. While oxidation-dependent pathways for demethylation have been de...

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Detalles Bibliográficos
Autores principales: Nabel, Christopher S., Jia, Huijue, Ye, Yu, Shen, Li, Goldschmidt, Hana L., Stivers, James T., Zhang, Yi, Kohli, Rahul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427411/
https://www.ncbi.nlm.nih.gov/pubmed/22772155
http://dx.doi.org/10.1038/nchembio.1042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427411/
https://www.ncbi.nlm.nih.gov/pubmed/22772155
http://dx.doi.org/10.1038/nchembio.1042

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