Mice lacking AMP-activated protein kinase α1 catalytic subunit have increased bone remodelling and modified skeletal responses to hormonal challenges induced by ovariectomy and intermittent PTH treatment

AMP-activated protein kinase (AMPK) is a key regulator of cellular and body energy homeostasis. We previously demonstrated that AMPK activation in osteoblasts increases in vitro bone formation while deletion of the Ampkα1 (Prkaa1) subunit, the dominant catalytic subunit expressed in bone, leads to d...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeyabalan, J, Shah, M, Viollet, B, Roux, J P, Chavassieux, P, Korbonits, M, Chenu, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioScientifica 2012
Materias:
Regular Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427644/
https://www.ncbi.nlm.nih.gov/pubmed/22700192
http://dx.doi.org/10.1530/JOE-12-0184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427644/
https://www.ncbi.nlm.nih.gov/pubmed/22700192
http://dx.doi.org/10.1530/JOE-12-0184

Ejemplares similares