Detection of Expression Quantitative Trait Loci in Complex Mouse Crosses: Impact and Alleviation of Data Quality and Complex Population Substructure

Complex Mus musculus crosses, e.g., heterogeneous stock (HS), provide increased resolution for quantitative trait loci detection. However, increased genetic complexity challenges detection methods, with discordant results due to low data quality or complex genetic architecture. We quantified the imp...

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Detalles Bibliográficos
Autores principales: Iancu, Ovidiu D., Darakjian, Priscila, Kawane, Sunita, Bottomly, Daniel, Hitzemann, Robert, McWeeney, Shannon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427913/
https://www.ncbi.nlm.nih.gov/pubmed/22969789
http://dx.doi.org/10.3389/fgene.2012.00157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427913/
https://www.ncbi.nlm.nih.gov/pubmed/22969789
http://dx.doi.org/10.3389/fgene.2012.00157

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