YcaO domains utilize ATP to activate amide backbones during peptide cyclodehydrations

Thiazole/oxazole-modified microcins (TOMMs) encompass a recently defined class of ribosomally synthesized natural products with a diverse set of biological activities. Although TOMM biosynthesis has been investigated for over a decade, the mechanism of heterocycle formation by the synthetase enzymes...

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Detalles Bibliográficos
Autores principales: Dunbar, Kyle L, Melby, Joel O, Mitchell, Douglas A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428213/
https://www.ncbi.nlm.nih.gov/pubmed/22522320
http://dx.doi.org/10.1038/nchembio.944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428213/
https://www.ncbi.nlm.nih.gov/pubmed/22522320
http://dx.doi.org/10.1038/nchembio.944

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