Suppression of Extensive Neurofilament Phosphorylation Rescues α-Internexin/Peripherin-Overexpressing PC12 Cells from Neuronal Cell Death

Intermediate filament (IF) overproduction induces abnormal accumulation of neuronal IF, which is a pathological indicator of some neurodegenerative disorders. In our study, α-Internexin- and peripherin-overexpressing PC12 cells (pINT-EGFP and pEGFP-peripherin) were used as models to study neuropatho...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Wen-Ching, Kan, Daphne, Chen, Yun-Yu, Han, Shan-Kuo, Lu, Kuo-Shyan, Chien, Chung-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428284/
https://www.ncbi.nlm.nih.gov/pubmed/22952800
http://dx.doi.org/10.1371/journal.pone.0043883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428284/
https://www.ncbi.nlm.nih.gov/pubmed/22952800
http://dx.doi.org/10.1371/journal.pone.0043883

Ejemplares similares