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Intracerebroventricular Injection of Metformin Induces Anorexia in Rats

BACKGROUND: Metformin, an oral biguanide insulin-sensitizing agent, is well known to decrease appetite. Although there is evidence that metformin could affect the brain directly, the exact mechanism is not yet known. METHODS: To evaluate whether metformin induces anorexia via the hypothalamus, vario...

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Detalles Bibliográficos
Autores principales: Lee, Chang Koo, Choi, Yoon Jung, Park, So Young, Kim, Jong Yeon, Won, Kyu Chang, Kim, Yong Woon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428418/
https://www.ncbi.nlm.nih.gov/pubmed/22950061
http://dx.doi.org/10.4093/dmj.2012.36.4.293