Pharmacokinetics of sepantronium bromide (YM155), a small-molecule suppressor of survivin, in Japanese patients with advanced solid tumors: dose proportionality and influence of renal impairment

PURPOSE: The purpose of this analysis was to investigate the pharmacokinetics (PK) of sepantronium (YM155), a small-molecule suppressor of the expression of the antiapoptosis protein survivin, in Japanese patients with advanced solid tumors and to evaluate the effect of renal impairment on the PK pr...

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Detalles Bibliográficos
Autores principales: Aoyama, Yumiko, Nishimura, Tetsuya, Sawamoto, Taiji, Satoh, Taroh, Katashima, Masataka, Nakagawa, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428524/
https://www.ncbi.nlm.nih.gov/pubmed/22806304
http://dx.doi.org/10.1007/s00280-012-1913-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428524/
https://www.ncbi.nlm.nih.gov/pubmed/22806304
http://dx.doi.org/10.1007/s00280-012-1913-z

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