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Pharmacokinetics of sepantronium bromide (YM155), a small-molecule suppressor of survivin, in Japanese patients with advanced solid tumors: dose proportionality and influence of renal impairment

PURPOSE: The purpose of this analysis was to investigate the pharmacokinetics (PK) of sepantronium (YM155), a small-molecule suppressor of the expression of the antiapoptosis protein survivin, in Japanese patients with advanced solid tumors and to evaluate the effect of renal impairment on the PK pr...

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Detalles Bibliográficos
Autores principales:	Aoyama, Yumiko, Nishimura, Tetsuya, Sawamoto, Taiji, Satoh, Taroh, Katashima, Masataka, Nakagawa, Kazuhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428524/ https://www.ncbi.nlm.nih.gov/pubmed/22806304 http://dx.doi.org/10.1007/s00280-012-1913-z

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