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Optogenetic silencing strategies differ in their effects on inhibitory synaptic transmission

Optogenetic silencing strategies using light-driven ion fluxes permit rapid and effective inhibition of neural activity. Using rodent hippocampal neurons we show that silencing activity with a chloride pump can increase the probability of synaptically-evoked spiking in the period following light-act...

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Detalles Bibliográficos
Autores principales: Raimondo, Joseph V., Kay, Louise, Ellender, Tommas J., Akerman, Colin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428858/
https://www.ncbi.nlm.nih.gov/pubmed/22729174
http://dx.doi.org/10.1038/nn.3143