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Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut
Regulatory T cells (T reg cells) are essential for the prevention of autoimmunity throughout life. T reg cell development occurs intrathymically but a subset of T reg cells can also differentiate from naive T cells in the periphery. In vitro, Smad signaling facilitates conversion of naive T cells in...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428940/ https://www.ncbi.nlm.nih.gov/pubmed/22908322 http://dx.doi.org/10.1084/jem.20112646 |