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Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut

Regulatory T cells (T reg cells) are essential for the prevention of autoimmunity throughout life. T reg cell development occurs intrathymically but a subset of T reg cells can also differentiate from naive T cells in the periphery. In vitro, Smad signaling facilitates conversion of naive T cells in...

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Detalles Bibliográficos
Autores principales:	Schlenner, Susan M., Weigmann, Benno, Ruan, Qingguo, Chen, Youhai, von Boehmer, Harald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428940/ https://www.ncbi.nlm.nih.gov/pubmed/22908322 http://dx.doi.org/10.1084/jem.20112646

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