Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

Tissue damage causes inflammation, by recruiting leukocytes and activating them to release proinflammatory mediators. We show that high-mobility group box 1 protein (HMGB1) orchestrates both processes by switching among mutually exclusive redox states. Reduced cysteines make HMGB1 a chemoattractant,...

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Detalles Bibliográficos
Autores principales: Venereau, Emilie, Casalgrandi, Maura, Schiraldi, Milena, Antoine, Daniel J., Cattaneo, Angela, De Marchis, Francesco, Liu, Jaron, Antonelli, Antonella, Preti, Alessandro, Raeli, Lorenzo, Shams, Sara Samadi, Yang, Huan, Varani, Luca, Andersson, Ulf, Tracey, Kevin J., Bachi, Angela, Uguccioni, Mariagrazia, Bianchi, Marco E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428943/
https://www.ncbi.nlm.nih.gov/pubmed/22869893
http://dx.doi.org/10.1084/jem.20120189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428943/
https://www.ncbi.nlm.nih.gov/pubmed/22869893
http://dx.doi.org/10.1084/jem.20120189

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