Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease

Lassa virus causes hemorrhagic fever characterized by immunosuppression. The nucleoprotein of Lassa virus, termed NP, binds the viral genome. It also has an additional enzymatic activity as an exonuclease that specifically digests double-stranded RNA (dsRNA). dsRNA is a strong signal to the innate i...

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Detalles Bibliográficos
Autores principales: Hastie, Kathryn M., King, Liam B., Zandonatti, Michelle A., Saphire, Erica Ollmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429428/
https://www.ncbi.nlm.nih.gov/pubmed/22937163
http://dx.doi.org/10.1371/journal.pone.0044211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429428/
https://www.ncbi.nlm.nih.gov/pubmed/22937163
http://dx.doi.org/10.1371/journal.pone.0044211

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