The Weak Complex between RhoGAP Protein ARHGAP22 and Signal Regulatory Protein 14-3-3 Has 1∶2 Stoichiometry and a Single Peptide Binding Mode

ARHGAP22 is a RhoGAP protein comprising an N-terminal PH domain, a RhoGAP domain and a C-terminal coiled-coil domain. It has recently been identified as an Akt substrate that binds 14-3-3 proteins in response to treatment with growth factors involved in cell migration. We used a range of biophysical...

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Detalles Bibliográficos
Autores principales: Hu, Shu-Hong, Whitten, Andrew E., King, Gordon J., Jones, Alun, Rowland, Alexander F., James, David E., Martin, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429473/
https://www.ncbi.nlm.nih.gov/pubmed/22952583
http://dx.doi.org/10.1371/journal.pone.0041731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429473/
https://www.ncbi.nlm.nih.gov/pubmed/22952583
http://dx.doi.org/10.1371/journal.pone.0041731

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