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The Weak Complex between RhoGAP Protein ARHGAP22 and Signal Regulatory Protein 14-3-3 Has 1∶2 Stoichiometry and a Single Peptide Binding Mode
ARHGAP22 is a RhoGAP protein comprising an N-terminal PH domain, a RhoGAP domain and a C-terminal coiled-coil domain. It has recently been identified as an Akt substrate that binds 14-3-3 proteins in response to treatment with growth factors involved in cell migration. We used a range of biophysical...
Autores principales: | Hu, Shu-Hong, Whitten, Andrew E., King, Gordon J., Jones, Alun, Rowland, Alexander F., James, David E., Martin, Jennifer L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429473/ https://www.ncbi.nlm.nih.gov/pubmed/22952583 http://dx.doi.org/10.1371/journal.pone.0041731 |
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