Cargando…

Potent Adjuvanticity of a Pure TLR7-Agonistic Imidazoquinoline Dendrimer

Engagement of toll-like receptors (TLRs) serve to link innate immune responses with adaptive immunity and can be exploited as powerful vaccine adjuvants for eliciting both primary and anamnestic immune responses. TLR7 agonists are highly immunostimulatory without inducing dominant proinflammatory cy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shukla, Nikunj M., Salunke, Deepak B., Balakrishna, Rajalakshmi, Mutz, Cole A., Malladi, Subbalakshmi S., David, Sunil A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429503/ https://www.ncbi.nlm.nih.gov/pubmed/22952720 http://dx.doi.org/10.1371/journal.pone.0043612

Ejemplares similares

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes
por: Ganapathi, Lakshmi, et al.
Publicado: (2015)

Identification of Adjuvantic Activity of Amphotericin B in a Novel, Multiplexed, Poly-TLR/NLR High-Throughput Screen
por: Salyer, Alex C. D., et al.
Publicado: (2016)

Synthesis and immunopharmacological evaluation of novel TLR7 agonistic triazole tethered imidazoquinolines
por: Avoni, Ayyappa, et al.
Publicado: (2023)

Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity
por: Beesu, Mallesh, et al.
Publicado: (2015)

An efficient and scalable synthesis of potent TLR2 agonistic PAM(2)CSK(4)
por: Kaur, Arshpreet, et al.
Publicado: (2018)

BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant
por: Kaushik, Deepender, et al.
Publicado: (2020)

Insights on the mechanism of action of immunostimulants in relation to their pharmacological potency. The effects of imidazoquinolines on TLR8
por: Kubli-Garfias, Carlos, et al.
Publicado: (2017)

Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
por: Yoo, Euna, et al.
Publicado: (2014)

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine
por: Jangra, Sonia, et al.
Publicado: (2020)

Flexible modulation of agonist efficacy at the human A(3 )adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000
por: Gao, Zhan-Guo, et al.
Publicado: (2008)

Adjuvants and adjuvanticity
por: Tizard, Ian R.
Publicado: (2021)

Synthesis, antibacterial, anti-oxidant and molecular docking studies of imidazoquinolines
por: Velmurugan, K., et al.
Publicado: (2021)

Acquired Drug Resistance Enhances Imidazoquinoline Efflux by P-Glycoprotein
por: Pulukuri, Anunay J., et al.
Publicado: (2021)

Control over Imidazoquinoline Immune Stimulation by pH-Degradable Poly(norbornene) Nanogels
por: Kockelmann, Johannes, et al.
Publicado: (2020)

Human Toll-Like Receptor 8-Selective Agonistic Activities in 1-Alkyl-1H-benzimidazol-2-amines
por: Beesu, Mallesh, et al.
Publicado: (2014)

Targeted Repolarization of Tumor‐Associated Macrophages via Imidazoquinoline‐Linked Nanobodies
por: Bolli, Evangelia, et al.
Publicado: (2021)

The inflammasome and alum-mediated adjuvanticity
por: Kang, Suk-Jo, et al.
Publicado: (2009)

Antigen depot is not required for alum adjuvanticity
por: Hutchison, Sharon, et al.
Publicado: (2012)

Vaccines of the Future: The Role of Inflammation and Adjuvanticity
por: Yun, Cheol-Heui, et al.
Publicado: (2015)

Cysteine Peptidases as Schistosomiasis Vaccines with Inbuilt Adjuvanticity
por: El Ridi, Rashika, et al.
Publicado: (2014)

Innate Immune Memory: The Latest Frontier of Adjuvanticity
por: Töpfer, Elfi, et al.
Publicado: (2015)

Influence of hydrocarbon oil structure on adjuvanticity and autoimmunity
por: Yau, Anthony C. Y., et al.
Publicado: (2017)

Was bringt die adjuvante Therapie des Melanoms?
Publicado: (2022)

Deglycosylation of eukaryotic-expressed flagellin restores adjuvanticity
por: Khim, Koemchhoy, et al.
Publicado: (2023)

Novel synthetic procedures for C2 substituted imidazoquinolines as ligands for the α/β-interface of the GABAA-receptor
por: Draskovits, Markus, et al.
Publicado: (2022)

Design and Structural Requirements of the Potent and Safe TLR-9 Agonistic Immunomodulator MGN1703
por: Schmidt, Manuel, et al.
Publicado: (2015)

Covalently Conjugated NOD2/TLR7 Agonists Are Potent and Versatile Immune Potentiators
por: Guzelj, Samo, et al.
Publicado: (2022)

Effects of KLK Peptide on Adjuvanticity of Different ODN Sequences
por: Chikh, Ghania, et al.
Publicado: (2016)

Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity
por: Li, Zhuofan, et al.
Publicado: (2021)

Adjuvanticity of β -Glucan for Vaccine Against Trichinella spiralis
por: Liu, Yi, et al.
Publicado: (2021)

Adjuvantation helps to optimise COVID-19 vaccine candidate
por: Li, Jing-Xin, et al.
Publicado: (2021)

Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles
por: Muñoz-Wolf, Natalia, et al.
Publicado: (2023)

Targeting Pattern Recognition Receptors (PRR) for Vaccine Adjuvantation: From Synthetic PRR Agonists to the Potential of Defective Interfering Particles of Viruses
por: Vasou, Andri, et al.
Publicado: (2017)

Imidazoquinolines with improved pharmacokinetic properties induce a high IFNα to TNFα ratio in vitro and in vivo
por: Keppler, Manuel, et al.
Publicado: (2023)

Adjuvantation of an Influenza Hemagglutinin Antigen with TLR4 and NOD2 Agonists Encapsulated in Poly(D,L-Lactide-Co-Glycolide) Nanoparticles Enhances Immunogenicity and Protection against Lethal Influenza Virus Infection in Mice
por: Tukhvatulin, Amir, et al.
Publicado: (2020)

Novel Lipidated Imidazoquinoline TLR7/8 Adjuvants Elicit Influenza-Specific Th1 Immune Responses and Protect Against Heterologous H3N2 Influenza Challenge in Mice
por: Miller, Shannon M., et al.
Publicado: (2020)

RNA is an Adjuvanticity Mediator for the Lipid-Based Mucosal Adjuvant, Endocine
por: Hayashi, Masayuki, et al.
Publicado: (2016)

Mast cells partially contribute to mucosal adjuvanticity of surfactin in mice
por: Yoshino, Naoto, et al.
Publicado: (2017)

Adjuvanticity of Processed Aloe vera gel for Influenza Vaccination in Mice
por: Song, Eun-Jung, et al.
Publicado: (2020)

The Potential Adjuvanticity of CAvant(®)SOE for Foot-and-Mouth Disease Vaccine
por: Ahn, Young-Hoon, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_j9eu8uhdt3d154scnhk5fa15h8