Screening for Novel LRRK2 Inhibitors Using a High-Throughput TR-FRET Cellular Assay for LRRK2 Ser935 Phosphorylation

BACKGROUND: Mutations in the leucine-rich repeat kinase-2 (LRRK2) have been linked to Parkinson’s disease. Recent studies show that inhibition of LRRK2 kinase activity decreased the level of phosphorylation at its own Ser910 and Ser935, indicating that these sites are prime targets for cellular read...

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Detalles Bibliográficos
Autores principales: Hermanson, Spencer B., Carlson, Coby B., Riddle, Steven M., Zhao, Jing, Vogel, Kurt W., Nichols, R. Jeremy, Bi, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429506/
https://www.ncbi.nlm.nih.gov/pubmed/22952710
http://dx.doi.org/10.1371/journal.pone.0043580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429506/
https://www.ncbi.nlm.nih.gov/pubmed/22952710
http://dx.doi.org/10.1371/journal.pone.0043580

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