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Can the exome and the immunome converge on the design of efficient cancer vaccines?

Human cancers carry hundreds of non-synonymous mutations, several dozens among which may lead to the generation of tumor-specific MHC Class I-restricted epitopes. Hence every patient’s tumor harbors a highly specific mutational and antigenic signature and up to 95% of these mutations are unique. Thi...

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Detalles Bibliográficos
Autores principales: Kroemer, Guido, Zitvogel, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429561/
https://www.ncbi.nlm.nih.gov/pubmed/22934249
http://dx.doi.org/10.4161/onci.20730