Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment

Regulatory T cells (Treg) have been reported of poor prognosis for overall survival in primary breast tumors (BT). As CCL22 plays a major role in Treg recruitment within primary BT we deciphered the mechanisms involved in the CCL22 production by breast epithelial tumor cells and propose herein the m...

Descripción completa

Detalles Bibliográficos
Autores principales: Ménétrier-Caux, Christine, Faget, Julien, Biota, Cathy, Gobert, Michael, Blay, Jean-Yves, Caux, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429586/
https://www.ncbi.nlm.nih.gov/pubmed/22934274
http://dx.doi.org/10.4161/onci.19680
Descripción
Sumario:Regulatory T cells (Treg) have been reported of poor prognosis for overall survival in primary breast tumors (BT). As CCL22 plays a major role in Treg recruitment within primary BT we deciphered the mechanisms involved in the CCL22 production by breast epithelial tumor cells and propose herein the major role of their innate immune recognition in this production.

Ejemplares similares